Changes in responsiveness of the canine basilar artery to endothelin-1 after subarachnoid hemorrhage

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(91)90006-W· OSTI ID:5380235

Kamata, Katsuo; Nishiyama, Hiroshi; Kasuya, Yutaka ^[1]; Miyata, Noriyuki ^[2]

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1. Taisho Pharmaceutical Co. Ltd., Saitama (Japan)
2. Hoshi Univ., Tokyo (Japan)

The effect of endothelin-1 (ET-1) on the basilar arteries from control and subarachnoid hemorrhage (SAH) dogs were examined. The maximal contraction of the basilar artery in response to ET-1 was markedly decreased in the SAH group. Treatment with 10{sup {minus}8}M phorbol 12-myristate 13-acetate (PMA) reduced the contractile responses to ET-1 in the basilar arteries from control dogs. ET-1-induced contractions of the basilar arteries from control dogs were similar to those in strips from SAH dogs by the treatment with 10{sup {minus}8}M PMA. Ca{sup 2+}-induced contraction of the basilar arteries which were depolarized with isotonic K{sup +} were significantly attenuated in SAH dogs. Treatment with PMA also reduced the contractile responses to Ca{sup 2+} in the basilar arteries from control dogs. These results indicate that decreased contractile responses of the basilar arteries to ET-1 and Ca{sup 2+} in the SAH group may be related to changes in the activity of the protein kinase C in vascular smooth muscle.

• OSTI ID: 5380235
• Journal Information: Life Sciences; (United States), Journal Name: Life Sciences; (United States) Vol. 49:3; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ARTERIES
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CARCINOGENS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CEREBRAL ARTERIES
CONTRACTION
DOGS
DRUGS
ENZYMES
ESTERS
HEMORRHAGE
MAMMALS
MUSCLES
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PEPTIDES
PHORBOL ESTERS
PHOSPHORUS-GROUP TRANSFERASES
PHOSPHOTRANSFERASES
PROTEINS
SYMPTOMS
TRANSFERASES
VASOCONSTRICTORS
VERTEBRATES