Thyroid uptake measurements with /sup 123/I: problems and pitfalls: concise communication

Journal Article · Sun Aug 01 04:00:00 EDT 1982 · J. Nucl. Med.; (United States)

OSTI ID:6568674

Chervu, S; Chervu, L R; Goodwin, P N; Blaufox, M D

The measurement of radioiodine uptake is generally considered to be straight-forward and accurate. However, during the past two decades, discrepancies in normal thyroid uptake values have been noticed between Montefiore Hospital and Medical Center and the Hospital of Albert Einstein College of Medicine. These differences were attributed to differences in patient population. Further investigation revealed that the persisting uptake discrepancies arose from neck-phantom differences and variations in procedure. Differences in presumably standardized neck-phantom attenuation characteristics have been shown to cause large variations in count rates from /sup 123/I and /sup 131/I standard capsules. The effect of high-voltage fluctuation on phantom count rates is more pronounced with /sup 123/I than with /sup 131/I. In constant levels of high-energy contaminants in /sup 123/-I also affect the uptake measurements. large errors in the measurements of thyroid uptake values may result from seemingly unimportant variations in technique. A stable high-voltage power supply, precise high-voltage adjustment, careful selection of energy window, and the use of a standardized neck phantom with generally accepted attenuation characteristics are absolutely essential if RAIU values are to be compared and appropriate therapeutic doses are to be administered based on these measurements.

• Research Organization: Albert Einstein College of Medicine, New York
• OSTI ID: 6568674
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:8; ISSN JNMEA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE 131
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
THYROID
UPTAKE