New method of calculating absolute thyroid activity in intravenous I-123 uptake tests
Journal Article
·
· Med. Phys.; (United States)
A technique for determining the absolute activity of I-123 in early thyroidal uptake tests is presented. The method is independent of geometry, tissue attenuation, and extrathyroidal neck activity (ENA). It utilizes the efficiency factors (ExT and E gamma T) derivable for the thyroid gland using coincidence counting techniques, and a quantity, alpha, characteristics of the vascularity of the individual patient. Although ENA is not determined in absolute terms (e.g., percent of injected dose), count rates due to ENA are determined. After subtracting the ENA from the total count rates thyroidal uptake can be determined as absolute activity by means of the efficiency factors. The validity and usefulness of the technique have been demonstrated in phantom and patient studies. Thyroid uptakes of less than 0.1% of injected dose can be measured accurately in our patient studies.
- OSTI ID:
- 5925344
- Journal Information:
- Med. Phys.; (United States), Journal Name: Med. Phys.; (United States) Vol. 7:6; ISSN MPHYA
- Country of Publication:
- United States
- Language:
- English
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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
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551001 -- Physiological Systems-- Tracer Techniques
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BETA DECAY RADIOISOTOPES
BIOLOGICAL MODELS
BODY
DIAGNOSTIC USES
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
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NUCLEI
ODD-EVEN NUCLEI
ORGANS
PATIENTS
PHANTOMS
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RADIONUCLIDE ADMINISTRATION
RADIONUCLIDE KINETICS
STRUCTURAL MODELS
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