Alteration of radioactive iodine uptake after treatment of hyperthyroidism with iodine 131

Journal Article · Sun May 01 00:00:00 EDT 1988 · South. Med. J.; (United States)

DOI:https://doi.org/10.1097/00007611-198805000-00015· OSTI ID:7190262

Heath, R C; Gossain, V V; Rovner, D R

To determine whether a therapeutic dose of iodine 131 affects the results of 24-hour radioactive iodine uptake (RAIU) testing, we reviewed records of hyperthyroid patients previously treated with /sup 131/I at Michigan State University and its affiliated hospitals. We identified 26 patients who had had clinical evaluation and determination of the serum thyroxine (T4) level, triiodothyronine resin uptake (T3RU), and RAIU (using /sup 131/I) within two weeks before and several months after the therapeutic dose of /sup 131/I. Before treatment, all patients had clinical hyperthyroidism, with an elevated T4 level and increased T3RU and RAIU. After treatment with /sup 131/I, eight patients (31%) had an RAIU that was discordant with their clinical and biochemical (T4 and T3RU) assessment. In six patients (23%) of the RAIU was inappropriately high, and in two patients (8%) it was inappropriately low. Since we did not identify any other factors known to interfere with the results of RAIU testing, we conclude that a therapeutic dose of /sup 131/I, may by itself increase or decrease a subsequent RAIU determination; therefore, after treatment with /sup 131/I, RAIU is not a good diagnostic index of thyroid activity.

• Research Organization: Michigan State Univ., East Lansing (USA)
• OSTI ID: 7190262
• Journal Information: South. Med. J.; (United States), Journal Name: South. Med. J.; (United States) Vol. 81:5; ISSN SMJOA
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
560161 -- Radionuclide Effects
Kinetics
& Toxicology-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
HYPERTHYROIDISM
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PATIENTS
PEPTIDE HORMONES
RADIOISOTOPES
RADIOLOGY
RADIONUCLIDE KINETICS
RADIOTHERAPY
THERAPY
THYROID
THYROID HORMONES
THYROXINE
TRIIODOTHYRONINE
UPTAKE