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Mutagenicity of soot and associated polycyclic aromatic hydrocarbons to Salmonella typhimurium

Journal Article · · Cancer Res.; (United States)
OSTI ID:6564292
; ;
The mutagenic activity of the polycyclic aromatic hydrocarbon-containing fraction of several soot samples was measured in Salmonella typhimurium, using resistance to the purine analog 8-azaguanine as a genetic marker. A postmitochondrial supernatant derived from livers of phenobarbital- and/or Aroclor-pretreated male Sprague-Dawley rats was incorporated into all assays to allow metabolism of promutagens to their active forms.
Research Organization:
Massachusetts, Inst. of Tech., Cambridge
OSTI ID:
6564292
Journal Information:
Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 39; ISSN CNREA
Country of Publication:
United States
Language:
English

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Related Subjects

560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BACTERIA
BENZOPYRENE
BIOASSAY
BIOLOGICAL EFFECTS
CONDENSED AROMATICS
HYDROCARBONS
METABOLISM
MICROORGANISMS
MUTAGENESIS
MUTATION FREQUENCY
ORGANIC COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
SALMONELLA
SALMONELLA TYPHIMURIUM
SENSITIVITY
SOOT
SYNERGISM
TOXICITY