Metastasis from uveal melanoma after proton beam irradiation

Journal Article · Fri Jul 01 04:00:00 EDT 1988 · Ophthalmology (Rochester, Minn.); (United States)

DOI:https://doi.org/10.1016/S0161-6420(88)33091-5· OSTI ID:6557608

Gragoudas, E S; Seddon, J M; Egan, K M; Glynn, R J; Goitein, M; Munzenrider, J; Verhey, L; Urie, M; Koehler, A

The incidence of metastasis and prognostic factors for metastasis in 780 consecutive patients with uveal melanomas treated with proton beam irradiation were evaluated. Metastasis developed in 64 patients (8%). The median time from treatment to the diagnosis of metastasis was 2.1 years (range, 3 months to 7.3 years). The liver was primarily involved in 58 (90%) patients. The 5-year cumulative probability of metastasis developing was 20%. Prognostic factors for metastasis developing were quite comparable to those found for patients treated by enucleation and included largest tumor diameter, involvement of the ciliary body, older age, and extrascleral extension. Surgical localization, tumor height, and elevated liver enzymes before treatment were not important factors in the development of metastasis.

• Research Organization: Massachusetts Eye and Ear Infirmary, Boston (USA)
• OSTI ID: 6557608
• Journal Information: Ophthalmology (Rochester, Minn.); (United States), Journal Name: Ophthalmology (Rochester, Minn.); (United States) Vol. 95:7; ISSN OPHTD
• Country of Publication: United States
• Language: English

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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DELAYED RADIATION EFFECTS
DISEASES
EYES
FACE
HEAD
MATHEMATICS
MEDICINE
MELANOMAS
METASTASES
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NUCLEAR MEDICINE
NUCLEON BEAMS
ORGANS
PARTICLE BEAMS
PATIENTS
PROTON BEAMS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
REGRESSION ANALYSIS
SENSE ORGANS
SIDE EFFECTS
STATISTICS
THERAPY
UVEA