Prognostic factors for metastasis following proton beam irradiation of uveal melanomas

Journal Article · Thu May 01 04:00:00 EDT 1986 · Ophthalmology (Rochester, Minn.); (United States)

DOI:https://doi.org/10.1016/S0161-6420(86)33699-6· OSTI ID:5119309

Gragoudas, E S; Seddon, J M; Egan, K M; Polivogianis, L; Hsieh, C C; Goitein, M; Verhey, L; Munzenrider, J; Austin-Seymour, M; Urie, M

Prognostic indicators for the development of metastasis following proton beam irradiation of uveal melanomas were evaluated for 510 patients treated from 1975 to 1984. Thirty-three patients developed metastasis (6.5%) from 3 to 51 months following treatment. The primary site of metastasis was the liver in 28 cases (85%). Both demographic and clinical factors were considered. The three leading predictors of survival without metastasis after proton beam irradiation in order of importance were: (1) largest diameter of the tumor; (2) location of the anterior margin of the tumor; and (3) age at treatment. Worse prognosis was associated with largest tumor diameter greater than 15.0 mm, tumor involvement of the ciliary body and age at treatment older than 59 years.

• OSTI ID: 5119309
• Journal Information: Ophthalmology (Rochester, Minn.); (United States), Journal Name: Ophthalmology (Rochester, Minn.); (United States) Vol. 5; ISSN OPHTD
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BARYONS
BODY
BODY AREAS
DIGESTIVE SYSTEM
DISEASES
ELEMENTARY PARTICLES
EYES
FACE
FERMIONS
GLANDS
HADRONS
HEAD
LIVER
MEDICINE
MELANOMAS
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEONS
ORGANS
PATIENTS
PROTONS
RADIOLOGY
RADIOTHERAPY
SENSE ORGANS
SURVIVAL TIME
THERAPY