Long-term results of proton beam irradiated uveal melanomas

Journal Article · Wed Apr 01 04:00:00 EST 1987 · Ophthalmology (Rochester, Minn.); (United States)

DOI:https://doi.org/10.1016/S0161-6420(87)33456-6· OSTI ID:6275542

Gragoudas, E S; Seddon, J M; Egan, K; Glynn, R; Munzenrider, J; Austin-Seymour, M; Goitein, M; Verhey, L; Urie, M; Koehler, A

The first 128 consecutive patients with uveal melanomas treated with proton beam irradiation were studied in order to evaluate survival and visual acuity status of patients with relatively long-term follow-up. The median follow-up was 5.4 years, and no patient was lost to follow-up. All tumors showed regression. The most recent visual acuity was 20/40 or better in 35% and 20/100 or better in 58%. Eight eyes were enucleated because of complications. Metastasis developed in 26 patients (20.5%) from 3 months to 7 years after treatment. Results indicate that proton irradiation is quite successful for achieving local control of uveal melanomas. A large proportion of the treated eyes maintained useful vision. Five-year follow-up data indicate that proton irradiation has no deleterious effect on the likelihood of the development of metastasis.

• Research Organization: Massachusetts Eye and Ear Infirmary, Boston
• OSTI ID: 6275542
• Journal Information: Ophthalmology (Rochester, Minn.); (United States), Journal Name: Ophthalmology (Rochester, Minn.); (United States) Vol. 4; ISSN OPHTD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BARYONS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DISEASES
ELEMENTARY PARTICLES
EYES
FACE
FERMIONS
HADRONS
HEAD
INJURIES
MEDICINE
MELANOMAS
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEON BEAMS
NUCLEONS
OPHTHALMOLOGY
ORGANS
PARTICLE BEAMS
PATIENTS
PROTON BEAMS
PROTONS
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
SENSE ORGANS
SURVIVAL CURVES
THERAPY
UVEA
VISION