Relative biological effectiveness of alpha-particle emitters in vivo at low doses
- Univ. of Medicine and Dentistry of New Jersey, Newark, NJ (United States)
The therapeutic potential of radionuclides that emit [alpha] particles, as well as their associated health hazards, have attracted considerable attention. The [sup 224]Ra daughters [sup 212]Pb and [sup 212]Bi, by virtue of their radiation properties which involve emission of [alpha] and [beta] particles in their decay to stable [sup 208]Pb, have been proposed as candidates for radioimmunotherapy. Using mouse testes as the experimental model and testicular spermhead survival as the biological end point, the present work examines the radiotoxicity of [sup 212]Pb and its daughters. When [sup 212]Pb, in equilibrium with its daughters [sup 212]Bi, [sup 212]Po and [sup 208]Tl, was administered directly into the testis, the dose required to achieve 37% survival (D[sub 37]) was 0.143 [+-] 0.014 Gy and the corresponding RBE of the mixed radiation field was 4.7 when compared to the D[sub 37] for acute external 120 kVp X rays. This datum, in conjunction with our earlier results for [sup 210]Po, was used to obtain an RBE-LET relationship for [alpha] particles emitted by tissue-incorporated radionuclides: RBE[sub [alpha]] = 4.8 - 6.1 x 10[sup [minus]2] LET + 1.0 x 10[sup [minus]3] LET[sup 2]. Similarly, the dependence of RBE on [alpha]-particle energy E[sub [alpha]] was given by RBE[sub [alpha]] = 22 E[sub [alpha]][sup [minus]0.73]. These relationships, based on in vivo experimental data, may be valuable in predicting biological effects of [alpha]-particle emitters. 46 refs., 6 figs.
- OSTI ID:
- 6551410
- Journal Information:
- Radiation Research; (United States), Vol. 137:3; ISSN 0033-7587
- Country of Publication:
- United States
- Language:
- English
Similar Records
Biological effect of lead-212 localized in the nucleus of mammalian cells: Role of recoil energy in the radiotoxicity of internal alpha-particle emitters
Comparison of short-lived high-LET alpha-emitting radionuclides lead-212 and bismuth-212 to low-LET X-rays on ovarian carcinoma
Related Subjects
99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
ALPHA PARTICLES
RBE
THERAPEUTIC USES
LOW DOSE IRRADIATION
DOSE-RESPONSE RELATIONSHIPS
CALCULATION METHODS
TESTES
BIOLOGICAL RADIATION EFFECTS
LEAD 212
LET
MICE
RADIOIMMUNOTHERAPY
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CHARGED PARTICLES
ENERGY TRANSFER
EVEN-EVEN NUCLEI
GONADS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMMUNOTHERAPY
IRRADIATION
ISOTOPES
LEAD ISOTOPES
MALE GENITALS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ORGANS
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RODENTS
THERAPY
USES
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture
990200 - Mathematics & Computers