skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Relative biological effectiveness of alpha-particle emitters in vivo at low doses

Abstract

The therapeutic potential of radionuclides that emit [alpha] particles, as well as their associated health hazards, have attracted considerable attention. The [sup 224]Ra daughters [sup 212]Pb and [sup 212]Bi, by virtue of their radiation properties which involve emission of [alpha] and [beta] particles in their decay to stable [sup 208]Pb, have been proposed as candidates for radioimmunotherapy. Using mouse testes as the experimental model and testicular spermhead survival as the biological end point, the present work examines the radiotoxicity of [sup 212]Pb and its daughters. When [sup 212]Pb, in equilibrium with its daughters [sup 212]Bi, [sup 212]Po and [sup 208]Tl, was administered directly into the testis, the dose required to achieve 37% survival (D[sub 37]) was 0.143 [+-] 0.014 Gy and the corresponding RBE of the mixed radiation field was 4.7 when compared to the D[sub 37] for acute external 120 kVp X rays. This datum, in conjunction with our earlier results for [sup 210]Po, was used to obtain an RBE-LET relationship for [alpha] particles emitted by tissue-incorporated radionuclides: RBE[sub [alpha]] = 4.8 - 6.1 x 10[sup [minus]2] LET + 1.0 x 10[sup [minus]3] LET[sup 2]. Similarly, the dependence of RBE on [alpha]-particle energy E[sub [alpha]] was given by RBE[submore » [alpha]] = 22 E[sub [alpha]][sup [minus]0.73]. These relationships, based on in vivo experimental data, may be valuable in predicting biological effects of [alpha]-particle emitters. 46 refs., 6 figs.« less

Authors:
; ; ;  [1]
  1. (Univ. of Medicine and Dentistry of New Jersey, Newark, NJ (United States))
Publication Date:
OSTI Identifier:
6551410
Resource Type:
Journal Article
Journal Name:
Radiation Research; (United States)
Additional Journal Information:
Journal Volume: 137:3; Journal ID: ISSN 0033-7587
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE; ALPHA PARTICLES; RBE; THERAPEUTIC USES; LOW DOSE IRRADIATION; DOSE-RESPONSE RELATIONSHIPS; CALCULATION METHODS; TESTES; BIOLOGICAL RADIATION EFFECTS; LEAD 212; LET; MICE; RADIOIMMUNOTHERAPY; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; CHARGED PARTICLES; ENERGY TRANSFER; EVEN-EVEN NUCLEI; GONADS; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; IMMUNOTHERAPY; IRRADIATION; ISOTOPES; LEAD ISOTOPES; MALE GENITALS; MAMMALS; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ORGANS; RADIATION EFFECTS; RADIOISOTOPES; RADIOLOGY; RADIOTHERAPY; RODENTS; THERAPY; USES; VERTEBRATES; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture; 990200 - Mathematics & Computers

Citation Formats

Howell, R.W., Azure, M.T., Narra, V.R., and Rao, D.V. Relative biological effectiveness of alpha-particle emitters in vivo at low doses. United States: N. p., 1994. Web. doi:10.2307/3578710.
Howell, R.W., Azure, M.T., Narra, V.R., & Rao, D.V. Relative biological effectiveness of alpha-particle emitters in vivo at low doses. United States. doi:10.2307/3578710.
Howell, R.W., Azure, M.T., Narra, V.R., and Rao, D.V. Tue . "Relative biological effectiveness of alpha-particle emitters in vivo at low doses". United States. doi:10.2307/3578710.
@article{osti_6551410,
title = {Relative biological effectiveness of alpha-particle emitters in vivo at low doses},
author = {Howell, R.W. and Azure, M.T. and Narra, V.R. and Rao, D.V.},
abstractNote = {The therapeutic potential of radionuclides that emit [alpha] particles, as well as their associated health hazards, have attracted considerable attention. The [sup 224]Ra daughters [sup 212]Pb and [sup 212]Bi, by virtue of their radiation properties which involve emission of [alpha] and [beta] particles in their decay to stable [sup 208]Pb, have been proposed as candidates for radioimmunotherapy. Using mouse testes as the experimental model and testicular spermhead survival as the biological end point, the present work examines the radiotoxicity of [sup 212]Pb and its daughters. When [sup 212]Pb, in equilibrium with its daughters [sup 212]Bi, [sup 212]Po and [sup 208]Tl, was administered directly into the testis, the dose required to achieve 37% survival (D[sub 37]) was 0.143 [+-] 0.014 Gy and the corresponding RBE of the mixed radiation field was 4.7 when compared to the D[sub 37] for acute external 120 kVp X rays. This datum, in conjunction with our earlier results for [sup 210]Po, was used to obtain an RBE-LET relationship for [alpha] particles emitted by tissue-incorporated radionuclides: RBE[sub [alpha]] = 4.8 - 6.1 x 10[sup [minus]2] LET + 1.0 x 10[sup [minus]3] LET[sup 2]. Similarly, the dependence of RBE on [alpha]-particle energy E[sub [alpha]] was given by RBE[sub [alpha]] = 22 E[sub [alpha]][sup [minus]0.73]. These relationships, based on in vivo experimental data, may be valuable in predicting biological effects of [alpha]-particle emitters. 46 refs., 6 figs.},
doi = {10.2307/3578710},
journal = {Radiation Research; (United States)},
issn = {0033-7587},
number = ,
volume = 137:3,
place = {United States},
year = {1994},
month = {3}
}