Radiotoxicity of gadolinium-148 and radium-223 in mouse testes: Relative biological effectiveness of alpha-particle emitters in vivo
- UMDNJ-New Jersey Medical School, Newark, NJ (United States); and others
The biological effects of radionuclides that emit {alpha} particles are of considerable interest in view of their potential for therapy and their presence in the environment. The present work is a continuation of our ongoing effort to study the radiotoxicity of {alpha}-particle emitters in vivo using the survival of murine testicular sperm heads as the biological end point. Specifically, the relative biological effectiveness (RBE) of very low-energy {alpha} particles (3.2 MeV) emitted by {sup 148}Gd is investigated and determined to be 7.4 {+-} 2.4 when compared to the effects of acute external 120 kVp X rays. This datum, in conjunction with our earlier results for {sup 210}Po and {sup 212}Pb in equilibrium with its daughters, is used to revise and extend the range of validity of our previous RBE-energy relationship for {alpha} particles emitted by tissue-incorporated radionuclides. The new empirical relationship is given by RBE{sub {alpha}} = 9.14 - 0.510 E{sub {alpha}}, where 3 < E{sub {alpha}} < 9 MeV. The validity of this empirical relationship is tested by determining the RBE of the prolific {alpha}-particle emitter {sup 223}Ra (in equilibrium with its daughters) experimentally in the same biological model and comparing the value obtained experimentally with the predicted value. The resulting RBE values are 5.4 {+-} 0.9 and 5.6, respectively. This close agreement strongly supports the adequacy of the empirical RBE-E{sub {alpha}} relationship to predict the biological effects of {alpha}-particle emitters in vivo. 42 refs., 5 figs., 1 tab.
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 535366
- Journal Information:
- Radiation Research, Vol. 147, Issue 3; Other Information: PBD: Mar 1997
- Country of Publication:
- United States
- Language:
- English
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