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Thermoradiotherapy of refractory malignant tumors: an experience with microwave and RF capacitive hyperthermia

Journal Article · · Med. Instrum. (Arlington, Va.); (United States)
OSTI ID:6548431
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Basic and clinical evidence that hyperthermia with radiation therapy or selected chemotherapy could significantly improve therapeutic ratios has attracted considerable interest. A variety of heating equipment and techniques have been used in many early clinical studies, with encouraging results: 60-70% with complete tumor regression without concomitant increase of normal-tissue toxicity. New generations of hyperthermia systems being developed should improve results significantly. However, since tumor response is directly related to hyperthermic temperature and the uniformity of the temperature distribution within target tissues, adequate characterization of the temperature profile within tumors as well as normal tissues is of primary importance. Clinical experience with microwave hyperthermia treatment combined with radiotherapy has been encouraging (complete regression response rate of 68% in 63 tumors in 50 patients) at Duke and VA Medical Centers, as have the results obtained (complete regression in 21 of 40 tumors treated in one clinic; 13 of 20 tumors treated in another clinic) with an 8-MHz RF capacitive hyperthermia system being evaluated in Japan.
Research Organization:
Department of Radiology, Duke University Medical Center, Durham, North Carolina
OSTI ID:
6548431
Journal Information:
Med. Instrum. (Arlington, Va.); (United States), Journal Name: Med. Instrum. (Arlington, Va.); (United States) Vol. 18:3; ISSN MLISB
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
560206 -- Thermal Effects-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BODY TEMPERATURE
DISEASES
ELECTROMAGNETIC RADIATION
HYPERTHERMIA
MEDICINE
MICROWAVE RADIATION
NEOPLASMS
NUCLEAR MEDICINE
OPTIMIZATION
PATIENTS
RADIATIONS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
TEMPERATURE EFFECTS
THERAPY