Local tumor hyperthermia in combination with radiation therapy. I. Malignant cutaneous lesions

Conference · Fri Jul 01 04:00:00 EDT 1977 · Cancer; (United States)

OSTI ID:7300331

Kim, J H ^[1]; Hahn, E W; Tokita, N; Nisce, L Z

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1. Memorial Sloan-Kettering Cancer Center, New York

There is increasing evidence that the use of hyperthermia alone or in conjunction with other modalities may improve the therapeutic effectiveness of treatment of cancer. The present clinical studies were carried out to evaluate the response of normal and tumor tissues in patients with various cutaneous malignant lesions to repeated courses of hyperthermia alone or in conjunction with radiation therapy. Thirty-six patients with malignant cutaneous lesions (mycosis fungoides, Kaposi sarcoma, malignant melanoma, lymphoma cutis, and other metastatic skin lesions) have been studied. The heating methods used were: temperature regulated water bath immersion; and radiofrequency inductive heating. The normal tissue effects of the combined treatments of radiation and hyperthermia do not appear to be greater than those treated with radiation alone. The initial tumor regression rates were faster in patients treated with radiation plus hyperthermia than in radiation alone, particularly in patients with Kaposi sarcoma and lymphoma cutis. Among ten locally recurrent patients, seven showed significant prolonged benefits achieved by the combined treatments as compared with the radiation therapy alone. Fractionated hyperthermia alone caused significant tumor regression in four out of five patients. Possible mechanisms leading to the improved results from the combined treatments are discussed.

• OSTI ID: 7300331
• Conference Information: Journal Name: Cancer; (United States) Journal Volume: 40:1
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BODY
BODY TEMPERATURE
DISEASES
EFFICIENCY
HYPERTHERMIA
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
SKIN
THERAPY
TISSUES