Radioimmunoassay of serum myoglobin in polymyositis and other conditions

Journal Article · Sat Jan 01 04:00:00 EST 1977 · Arthritis Rheum.; (United States)

DOI:https://doi.org/10.1002/art.1780200811· OSTI ID:6540658

Nishikai, M; Reichlin, M

Radioimmunoassay of serum myoglobin was done in 53 patients with polymyositis syndromes and other conditions. Serum myoglobin values in 33 healthy subjects ranged from 4 to 77 (mean 33.3 +/- 19.8 (SD)) ng/ml. Fifty percent of polymyositis patients had elevated serum myoglobin levels (greater than 80 ng/ml). Serum myoglobin values in polymyositis patients fluctuated more sensitively than CPK and GOT. Combined estimation of myoglobin and CPK offers advantages for the detection of muscle injury and the prediction of disease exacerbation.

• Research Organization: State Univ. of New York School of Medicine, Buffalo
• OSTI ID: 6540658
• Journal Information: Arthritis Rheum.; (United States), Journal Name: Arthritis Rheum.; (United States) Vol. 20:8; ISSN ARHEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARBOXYLIC ACIDS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ELEMENTS
GLOBIN
HALOGENS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INJURIES
IODINE
ISOTOPE APPLICATIONS
ISOTOPES
MUSCLES
MYOGLOBIN
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATIENTS
PIGMENTS
PORPHYRINS
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
TRACER TECHNIQUES
USES