Effect of ethanol on the retention of americium-241 in the baboon liver

Journal Article · Fri Sep 01 00:00:00 EDT 1978 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397809529703· OSTI ID:6540033

Cohen, N; Antonelli, R; Lo Sasso, T; Wrenn, M E

The oral administration of ethyl alcohol enhanced the excretion of /sup 241/Am from the liver of a baboon by 2.5 times that of a control animal. After ethanol administration, increases in the total content of /sup 241/Am excreted in feces were accompanied by corresponding increases in fecal volumes, although administration of nonalcoholic cathartics would not be expected to produce a similar effect. The effectiveness of ethanol as a decorporating agent may result from its ability to mobilize intracellularly bound /sup 241/Am from the liver, thereby making the nuclide more available for metabolic secretory mechanism occurring via the liver-bile-fecal route.

• Research Organization: New York Univ., NY
• OSTI ID: 6540033
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 4:5-6; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALCOHOLS
ALPHA DECAY RADIOISOTOPES
AMERICIUM 241
AMERICIUM COMPOUNDS
AMERICIUM ISOTOPES
ANIMALS
APES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
CARBOXYLIC ACID SALTS
CITRATES
CLEANING
CLEARANCE
DECONTAMINATION
DIGESTIVE SYSTEM
ETHANOL
EXCRETION
FECES
GLANDS
HEAVY NUCLEI
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOTOPES
LIVER
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RETENTION
TRANSPLUTONIUM ELEMENT COMPOUNDS
TRANSURANIUM COMPOUNDS
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES