Saccharin-induced sister chromatid exchanges in Chinese hamster and human cells

Journal Article · Fri May 05 00:00:00 EDT 1978 · Science; (United States)

DOI:https://doi.org/10.1126/science.644315· OSTI ID:6539742

Wolff, S; Rodin, B

Since the induction of sister chromatid exchanges in cultured cells has been shown to be the most sensitive mammalian system to detect the effects of mutagenic carcinogens, Chinese hamster ovary cells and human lymphocytes were exposed to the sodium saccharin found to induce bladder cancer in rats. Both that saccharin and a highly purified extract of it increased the yield of sister chromatid exchanges in both types of cells. The results, which were repeatable and statistically highly significant, indicated that the weak carcinogen, saccharin, is also mutagenic in the sense that it induces cytogenetic changes.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 6539742
• Journal Information: Science; (United States), Journal Name: Science; (United States) Vol. 200:4341; ISSN SCIEA
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARCINOGENESIS
CELL CULTURES
CHROMATIDS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
HAMSTERS
HETEROCYCLIC COMPOUNDS
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MAN
MUTAGENESIS
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PATHOGENESIS
PRIMATES
RODENTS
SACCHARIN
SOMATIC CELLS
THIAZOLES
VERTEBRATES