Effects of NO/sub 2/ on the response of baboon alveolar macrophages to migration inhibitory factor

Journal Article · Fri Sep 01 04:00:00 EDT 1978 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397809529708· OSTI ID:6539539

Greene, N D; Schneider, S L

Pulmonary alveolar macrophages (PAM) were obtained by lavage from baboons exposed for 6 mo to 2 ppM NO/sub 2/ for 8 h/d, 5 d/wk, and the response of these cells to autologous migration inhibitory factor (MIF) was determined. The PAM from two of three antigen-stimulated, NO/sub 2/-exposed animals failed to respond to MIF derived from antigen-sensitized autologous lymphocytes. Similarly, PAM from three of the four NO/sup 2/-exposed animals had diminished responsiveness to MIF obtained by phytohemagglutinin stimulation of their own lymphocytes. The altered responsiveness resulted from an effect on the macrophages and not on the lymphocytes used to prepare the MIF, as shown by the normal blastogenic responsiveness of the lymphocytes and the normal activity of the MIF thus produced on guinea pig peritoneal macrophages. These results demonstrate that inhalation of 2 ppM NO/sub 2/ may have important subtle effects on pulmonary cells, which may result in altered immune capabilities within the lung.

• Research Organization: Southwest Foundation for Research and Education, San Antonio, TX
• OSTI ID: 6539539
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 4:5-6; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
APES
BIOLOGICAL EFFECTS
CHALCOGENIDES
CHRONIC EXPOSURE
CONNECTIVE TISSUE CELLS
EXPOSURE CHAMBERS
IMMUNE REACTIONS
INHALATION
INHIBITION
INTAKE
MACROPHAGES
MAMMALS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
PHAGOCYTES
PRIMATES
RESPIRATORY TRACT CELLS
SOMATIC CELLS
VERTEBRATES