Chromosome aberrations and cell survival in irradiated mammalian cells
Journal Article
·
· Radiat. Res.; (United States)
A possible correlation between chromosome aberrations and reduced proliferation capacity or cell death was investigated. Synchronized Chinese hamster fibroblast cells were irradiated with 300 rad of x rays in early G/sub 1/. Despite synchronization the cells reached the subsequent mitosis at different times. The frequency of chromosome aberrations was determined in the postirradiation division at 2-h intervals. The highest frequency occurred in cells with a first cell cycle of medium length. The colony-forming ability of mitotic cells was measured in parallel samples by following the progress of individual mitoses. The proportion of cells forming macrocolonies decreased with increasing cell cycle length, and the number of non-colony-forming cells increased. Irrespective of various first cell cycle lengths and different frequencies of chromosome aberrations, the number of cells forming microcolonies remained constant. A correlation was found between the absence of chromosome aberrations and the ability of cells to form macrocolonies. However, cells with a long first cell cycle formed fewer macrocolonies than expected.
- Research Organization:
- Univ., Zurich, Switzerland
- OSTI ID:
- 6538554
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 85:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Fri Nov 30 23:00:00 EST 1973
· Mutat. Res., v. 20, no. 3, pp. 387-402
·
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Related Subjects
560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
CELL CYCLE
CELL DIVISION
CELL KILLING
CELL PROLIFERATION
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DELAYED RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FIBROBLASTS
HAMSTERS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MITOSIS
MUTATIONS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
VERTEBRATES
X RADIATION
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
CELL CYCLE
CELL DIVISION
CELL KILLING
CELL PROLIFERATION
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DELAYED RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FIBROBLASTS
HAMSTERS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MITOSIS
MUTATIONS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
VERTEBRATES
X RADIATION