Cytogenetic study on workers exposed to low concentrations of benzene

Journal Article · Fri Jun 01 04:00:00 EDT 1984 · Carcinogenesis (N.Y.); (United States)

DOI:https://doi.org/10.1093/carcin/5.6.827· OSTI ID:6536671

Sarto, F; Cominato, I; Pinton, A M; Brovedani, P G; Merler, E; Peruzzi, M; Bianchi, V; Levis, A G

A cytogenetic study was performed on 22 healthy workers engaged in benzene production and exposed to low concentrations of benzene, ranging from 0.2 to 12.4 p.p.m. (threshold limit value 10 p.p.m.). Workers were divided into two groups according to the different levels of exposure, inferrable also from the concentration of benzene in the alveolar air and the levels of urinary phenols. Each exposed subject was paired with a suitable control, living in the same area and of similar smoking habits and age. No statistically significant increase of sister chromatid exchange (SCE) frequency was observed in the exposed groups. In controls, SCE frequency was positively correlated with age and smoking habits. Among structural chromosomal aberrations, only the chromosome-type ones were significantly higher in exposed than in control subjects, and their increase was still significant when gaps were discarded.

• Research Organization: Universita di Padova, Padua, Italy
• OSTI ID: 6536671
• Journal Information: Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 5:6; ISSN CRNGD
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AGE DEPENDENCE
AIR POLLUTION
ANIMAL CELLS
AROMATICS
BENZENE
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CHEMICAL ANALYSIS
CHROMOSOMAL ABERRATIONS
CLEARANCE
COLLOIDS
DISPERSIONS
EXCRETION
EXHALATION
GENETIC EFFECTS
HYDROCARBONS
HYDROXY COMPOUNDS
MATERIALS
MUTATIONS
OCCUPATIONAL EXPOSURE
ORGANIC COMPOUNDS
PHENOLS
POLLUTION
RESIDUES
SISTER CHROMATID EXCHANGES
SMOKES
SOLS
TOBACCO SMOKES
URINE
WASTES