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Mutagenesis of dimeric plasmids by the transposon. gamma. delta. (Tn1000)

Journal Article · · Journal of Bacteriology; (USA)
OSTI ID:6534210
;  [1]
  1. Univ. of Connecticut, Storrs (USA)

The Escherichia coli F factor mediates conjugal transfer of a plasmid such as pBR322 primarily by replicative transposition of transposon {gamma}{delta} (Tn1000) from F to that plasmid to form a cointegrate intermediate. Although resolution of this cointegrate always yields a plasmid containing a single {gamma}{delta} insertion, the occasional recovery of transposon-free plasmids after connuugal transfer has led to alternative hypotheses for F mobilization. The authors show here that {gamma}{delta}-free plasmids are found after F-mediated conjugal transfer only when the donor plasmid is a dimer and the recipient is Rec{sup +}.

DOE Contract Number:
FG02-89ER60862
OSTI ID:
6534210
Journal Information:
Journal of Bacteriology; (USA), Journal Name: Journal of Bacteriology; (USA) Vol. 172:5; ISSN JOBAA; ISSN 0021-9193
Country of Publication:
United States
Language:
English

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