Production of arachidonic and linoleic acid metabolites by guinea pig tracheal epithelial cells

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · Inflammation (New York); (USA)

DOI:https://doi.org/10.1007/BF00914091· OSTI ID:6532180

Oosthuizen, M J; Engels, F; Van Esch, B; Henricks, P A; Nijkamp, F P ^[1]

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1. State Univ. of Utrecht (Netherlands)

Pulmonary epithelial cells may be responsible for regulating airway smooth muscle function, in part by release of fatty acid-derived mediators. Incubation of isolated guinea pig tracheal epithelial cells with radiolabeled arachidonic acid (AA) leads to the production of 5- and 15-hydroxyeicosatetraenoic acid (5- and 15-HETE) and smaller amounts of leukotriene (LT) B4 and C4 and 12-hydroxyheptadecatrienoic acid (HHT). Epithelial cells also are able to release linoleic acid (LA) metabolites. Incubation with radiolabeled linoleic acid leads to the formation of 9- and 13-hydroxyoctadecadienoic acid (9- and 13-HODE). The biological significance of these mediators produced by epithelial cells is discussed.

• OSTI ID: 6532180
• Journal Information: Inflammation (New York); (USA), Journal Name: Inflammation (New York); (USA) Vol. 14:4; ISSN INFLD; ISSN 0360-3997
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMAL TISSUES
ANIMALS
ARACHIDONIC ACID
BODY
CARBON ISOTOPES
CARBOXYLIC ACIDS
EPITHELIUM
GUINEA PIGS
ISOTOPE APPLICATIONS
ISOTOPES
LINOLEIC ACID
MAMMALS
METABOLISM
MONOCARBOXYLIC ACIDS
MUSCLES
ORGANIC ACIDS
ORGANIC COMPOUNDS
RESPIRATORY SYSTEM
RODENTS
TISSUES
TRACER TECHNIQUES
TRACHEA
VERTEBRATES