Quantification of patterns of regional cardiac metabolism

Journal Article · Sat Sep 01 00:00:00 EDT 1990 · Radiology; (USA)

DOI:https://doi.org/10.1148/radiology.176.3.2389023· OSTI ID:6528796

Lear, J L; Ackermann, R F ^[1]

---

1. Univ. of Colorado Health Sciences Center, Denver (USA)

To quantitatively map and compare patterns of regional cardiac metabolism with greater spatial resolution than is possible with positron emission tomography (PET), the authors developed autoradiographic techniques for use with combinations of radiolabeled fluorodeoxyglucose (FDG), glucose (GLU), and acetate (ACE) and applied the techniques to normal rats. Kinetic models were developed to compare GLU-based oxidative glucose metabolism with FDG-based total glucose metabolism (oxidative plus anaerobic) and to compare ACE-based overall oxidative metabolism with FDG-based total glucose metabolism. GLU-based metabolism generally paralleled FDG-based metabolism, but divergence occurred in certain structures such as the papillary muscles, where FDG-based metabolism was much greater. ACE-based metabolism also generally paralleled FDG-based metabolism, but again, the papillary muscles had relatively greater FDG-based metabolism. These discrepancies between FDG-based metabolism and GLU- or ACE-based metabolism suggest the presence of high levels of anaerobic glycolysis. Thus, the study indicates that anaerobic glycolysis, in addition to occurring in ischemic or stunned myocardium (as has been shown in recent PET studies), occurs normally in specific cardiac regions, despite the presence of abundant oxygen.

• OSTI ID: 6528796
• Journal Information: Radiology; (USA), Journal Name: Radiology; (USA) Vol. 176:3; ISSN RADLA; ISSN 0033-8419
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACETATES
ALDEHYDES
ANIMALS
AUTORADIOGRAPHY
BODY
CARBOHYDRATES
CARBOXYLIC ACID SALTS
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
GLUCOSE
HEART
HEXOSES
ISOTOPES
MAMMALS
METABOLISM
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
RATS
RODENTS
SACCHARIDES
TOMOGRAPHY
VERTEBRATES