Deficiency of liver-X-receptor-α reduces glucose uptake and worsens post-myocardial infarction remodeling

Journal Article · Sat Jul 01 04:00:00 EDT 2017 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2017.05.072· OSTI ID:22719010

Ji, Qingqi; Zhao, Yichao; Yuan, Ancai; Pu, Jun; He, Ben

Liver X receptor α (LXRα) is an endogenous protective receptor against ischemic heart diseases. However, whether LXRα regulated glucose metabolism in ischemic heart diseases has not been investigated. In this study we investigated the involvement of LXRα on glucose metabolism in cardiac remodeling after myocardial infarction (MI). MI was induced in mice by permanent ligation of the left anterior descending coronary artery (LCA). Genetic LXRα deletion significantly worsened cardiac remodeling and impaired cardiac function at 4 weeks after MI. Cardiac 18F-fluorodeoxyglucose (FDG) uptake by positron emission tomography (PET) demonstrated that the FDG standardized uptake value (SUV) was significantly lower in LXRα{sup −/−} mice as compared to WT mice. Mechanistically, GLUT1/4 and AMPK phosphorylation were significantly downregulated while CD36 expression was markedly upregulated in LXRα{sup −/−} mice. This study demonstrated that deficiency of LXRα decreased glucose uptake after MI, resulting in a metabolic shift that suppressed glucose metabolism, which was in association with adverse cardiac remodeling. - Highlights: • Deficiency of LXRα reduced glucose uptake after myocardial infarction (MI). • Loss of LXRα downregulated GLUT1/4 expressions in response to MI. • Targeting LXRα to promote glucose uptake may protect against cardiac remodeling.

• OSTI ID: 22719010
• Journal Information: Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 3 Vol. 488; ISSN BBRCA9; ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
CORONARIES
FLUORINE 18
FLUORODEOXYGLUCOSE
GLUCOSE
HEART
ISCHEMIA
LIVER
METABOLISM
MICE
MYOCARDIAL INFARCTION
PHOSPHORYLATION
POSITRON COMPUTED TOMOGRAPHY
RECEPTORS
UPTAKE