Review of /sup 1/H nuclear magnetic resonance relaxation in pathology: are T1 and T2 diagnostic

Journal Article · Thu Jan 01 04:00:00 EST 1987 · Med. Phys.; (United States)

OSTI ID:6522972

Bottomley, P A; Hardy, C J; Argersinger, R E; Allen-Moore, G

The longitudinal (T1) and transverse (T2) proton (1H) nuclear magnetic resonance (NMR) relaxation times of pathological human and animal tissues in the frequency range 1-100 MHz are archived, reviewed, and analyzed as a function of tissue of origin, NMR frequency, temperature, species, and in vivo versus in vitro status. T1 data from specific disease states of the bone, brain, breast, kidney, liver, muscle, pancreas, and spleen can be characterized by simple dispersions of the form T1 = AvB in the range 1-100 MHz with A and B empirically determined pathology-dependent constants. Pathological tissue T2 values are essentially independent of NMR frequency. Raw relaxation data, best-fit T1 parameters A and B, and the mean T2 values, are tabulated along with standard deviations and sample size to establish the normal range of pathological tissue relaxation times applicable to NMR imaging or in vitro NMR examination. Statistical analysis of relaxation data, assumed independent, reveals that most tumor and edematous tissue T1 values and some breast, liver, and muscle tumor T2 values are significantly elevated relative to normal, but do not differ significantly from other tumors and pathologies. Statistically significant abnormalities in the T1 values of some brain, breast, and lung tumors, and most pathological tissue T2 values could not, however, be demonstrated in the presence of large statistical errors. Both T1 and T2 in uninvolved tissue from tumor-bearing animals or organs do not demonstrate statistically significant differences from normal when considered as a group, suggesting no appreciable systemic effects associated with the presence of tumors compared to the statistical uncertainty.261 references. (Abstract Truncated)

• Research Organization: General Electric Corporate Research and Development Center, Schenectady, NY
• OSTI ID: 6522972
• Journal Information: Med. Phys.; (United States), Journal Name: Med. Phys.; (United States) Vol. 1; ISSN MPHYA
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
BARYONS
BIOPHYSICS
BODY
DIAGNOSTIC USES
DISEASES
DOCUMENT TYPES
ELEMENTARY PARTICLES
FERMIONS
FREQUENCY RANGE
HADRONS
MAGNETIC RESONANCE
MHZ RANGE
MHZ RANGE 01-100
NEOPLASMS
NUCLEAR MAGNETIC RESONANCE
NUCLEONS
PATHOLOGY
PROTONS
RELAXATION TIME
RESONANCE
REVIEWS
TISSUES
USES