Effect of ribose on thallium-201 myocardial redistribution

Journal Article · Thu Dec 01 00:00:00 EST 1988 · J. Nucl. Med.; (United States)

OSTI ID:6516809

Angello, D A; Wilson, R A; Gee, D

Myocardial S Tl redistribution after transient ischemia may be too slow to allow identification of a reversible myocardial defect within the routine S Tl imaging period. To determine whether S Tl redistribution could be affected by a metabolic intervention, intravenous ribose was administered postischemia. Seventeen domestic swine were subjected to a 10-min ischemic period followed by either a 30-min i.v. ribose (n = 8) or saline (n = 9) infusion. Thallium-201 was injected during ischemia and myocardial S Tl activity was continuously monitored in ischemic and nonischemic regions with miniature CdTe radiation detection probes. Coronary flow in the ischemic region was reduced to 25% of that in the nonischemic regions in both saline and ribose groups. The S Tl time-activity curves demonstrated a significant enhancement of % S Tl redistribution in the ribose-treated animals at the end of ribose infusion: Ribose (48 +/- 11%), Saline (20 +/- 4%), p less than 0.05. Alteration of S Tl kinetics by ribose may permit earlier recognition of S Tl myocardial redistribution after transient ischemia.

• Research Organization: Oregon Health Sciences Univ., Portland (USA)
• OSTI ID: 6516809
• Journal Information: J. Nucl. Med.; (United States), Vol. 29:12
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
BLOOD FLOW
ISCHEMIA
DIAGNOSIS
THALLIUM 201
UPTAKE
MYOCARDIUM
RIBOSE
SWINE
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MONOSACCHARIDES
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PENTOSES
RADIOISOTOPES
SACCHARIDES
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
VASCULAR DISEASES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics