Effect of ribose on thallium-201 myocardial redistribution

Journal Article · Thu Dec 01 04:00:00 EST 1988 · J. Nucl. Med.; (United States)

OSTI ID:6516809

Angello, D A; Wilson, R A; Gee, D

Myocardial S Tl redistribution after transient ischemia may be too slow to allow identification of a reversible myocardial defect within the routine S Tl imaging period. To determine whether S Tl redistribution could be affected by a metabolic intervention, intravenous ribose was administered postischemia. Seventeen domestic swine were subjected to a 10-min ischemic period followed by either a 30-min i.v. ribose (n = 8) or saline (n = 9) infusion. Thallium-201 was injected during ischemia and myocardial S Tl activity was continuously monitored in ischemic and nonischemic regions with miniature CdTe radiation detection probes. Coronary flow in the ischemic region was reduced to 25% of that in the nonischemic regions in both saline and ribose groups. The S Tl time-activity curves demonstrated a significant enhancement of % S Tl redistribution in the ribose-treated animals at the end of ribose infusion: Ribose (48 +/- 11%), Saline (20 +/- 4%), p less than 0.05. Alteration of S Tl kinetics by ribose may permit earlier recognition of S Tl myocardial redistribution after transient ischemia.

• Research Organization: Oregon Health Sciences Univ., Portland (USA)
• OSTI ID: 6516809
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 29:12; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BODY
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MONOSACCHARIDES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PENTOSES
RADIOISOTOPES
RIBOSE
SACCHARIDES
SECONDS LIVING RADIOISOTOPES
SWINE
THALLIUM 201
THALLIUM ISOTOPES
UPTAKE
VASCULAR DISEASES
VERTEBRATES