Ribose facilitates thallium-201 redistribution in patients with coronary artery disease

Journal Article · Fri Feb 01 00:00:00 EST 1991 · Journal of Nuclear Medicine; (USA)

OSTI ID:6009346

Perlmutter, N S; Wilson, R A; Angello, D A; Palac, R T; Lin, J; Brown, B G ^[1]

---

1. Oregon Health Sciences Univ., Portland (USA)

To investigate whether i.v. infusion of ribose, an adenine nucleotide precursor, postischemia facilitates thallium-201 (201Tl) redistribution and improves identification of ischemic myocardium in patients with coronary artery disease (CAD), 17 patients underwent two exercise 201Tl stress tests, performed 1-2 wk apart. After immediate postexercise planar imaging, patients received either i.v. ribose (3.3 mg/kg/min x 30 min) or saline as a control. Additional imaging was performed 1 and 4 hr postexercise. Reversible defects were identified by count-profile analysis. Significantly more (nearly twice as many) reversible 201Tl defects were identified on the post-ribose images compared to the post-saline (control) images at both 1 and 4 hr postexercise (p less than 0.001). Quantitative analyses of the coronary arteriogram was available in 13 patients and confirmed that the additional reversible defects were in myocardial regions supplied by stenosed arteries. We conclude that ribose appears to facilitate 201Tl redistribution in patients with CAD and enhances identification of ischemic myocardium.

• OSTI ID: 6009346
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 32:2; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ISCHEMIA
DIAGNOSIS
RIBOSE
BIOLOGICAL FUNCTIONS
ADENINES
EXERCISE
MYOCARDIUM
PATIENTS
RADIOISOTOPE SCANNING
THALLIUM 201
ALDEHYDES
AMINES
ANTIMETABOLITES
AROMATICS
AZAARENES
BETA DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
FUNCTIONS
HEART
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MONOSACCHARIDES
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PENTOSES
PURINES
RADIOISOTOPES
SACCHARIDES
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
VASCULAR DISEASES
550601* - Medicine- Unsealed Radionuclides in Diagnostics