Inactivation of human T-lymphotropic virus type III/lymphadenopathy-associated virus by formaldehyde-based reagents

Journal Article · Wed Apr 01 00:00:00 EST 1987 · Appl. Environ. Microbiol.; (United States)

OSTI ID:6516420

Martin, L S; Loskoski, S L; McDougal, J S

Neutral buffered Formalin, a fixative used in most pathology laboratories, was found to inactivate human T-lymphotropic virus type III/lymphadenopathy-associated virus. Preparations containing this virus with infectivity titers of > 10/sup 5/ were treated with 1% or greater neutral buffered Formalin; after treatment, virus was undetectable (titer, <10/sup 1/). In addition, when infected phytohemagglutinin-stimulated lymphocytes were treated with paraformaldehyde, transmission of the virus to other such lymphocytes was eliminated. 4 references, 2 tables.

• Research Organization: Centers for Disease Control, Atlanta, GA
• OSTI ID: 6516420
• Journal Information: Appl. Environ. Microbiol.; (United States), Vol. 53:4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
FORMALDEHYDE
TOXICITY
VIRUSES
INFECTIVITY
EXPERIMENTAL DATA
INACTIVATION
LYMPHOCYTES
MAN
ALDEHYDES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DATA
INFORMATION
LEUKOCYTES
MAMMALS
MATERIALS
MICROORGANISMS
NUMERICAL DATA
ORGANIC COMPOUNDS
PARASITES
PRIMATES
SOMATIC CELLS
VERTEBRATES
560300* - Chemicals Metabolism &amp; Toxicology