Effect of hyperthermia and misonidazole on the radiosensitivity of a transplant murine tumor: influence of factors modifying the fraction of hypoxic cells

Journal Article · Sun Aug 01 04:00:00 EDT 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90582-X· OSTI ID:6514534

Wondergem, J; Haveman, J; van der Schueren, E; van den Hoeven, H; Breur, K

Hypoxia has been demonstrated to play an important role in the effect of hyperthermia on tumors. The influence of different factors modifying the oxygenation status of a transplantable murine mammary adenocarcinoma has been studied. The effect of hyperthermia alone on the tumor is not significantly influenced by the change in oxygenation status during the growth of the tumor. Also, the large increase of the acutely hypoxic cell fraction, as a result of anesthesia, does not change the effect of hyperthermia alone. In the combined irradiation-heat treatment there is a clear influence of the chronically hypoxic cell fraction on the response to hyperthermia: an increase in tumor size, resulting in a larger hypoxic cell fraction, leads to an increase in thermal enhancement ratio. However, the increased acutely hypoxic cell fraction, resulting from anesthesia, did not lead to an increase in thermal enhancement ratio; in fact the enhancement ratio apparently decreased. In spite of the fact that hyperthermia was applied immediately after irradiation no potentiation of radiation effects was found. The thermal enhancement of the radiation response was never larger than the enhancement as a result of misonidazole.

• Research Organization: Univ. of Amsterdam, Netherlands
• OSTI ID: 6514534
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 8:8; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANOXIA
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY TEMPERATURE
DRUGS
EXPERIMENTAL NEOPLASMS
HETEROCYCLIC COMPOUNDS
HYPERTHERMIA
IMIDAZOLES
MAMMALS
MICE
MISONIDAZOLE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RODENTS
VERTEBRATES