Effect of hyperglycemia on the tumor response to irradiation given alone or in combination with hyperthermia

Journal Article · Tue Sep 01 04:00:00 EDT 1987 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576934· OSTI ID:5625919

Urano, M; Todoroki, T; Kahn, J; Okunieff, P

The effect of hyperglycemia (elevated blood glucose level) on the response of a murine tumor to irradiation given alone or in combination with hyperthermia was studied. Tumors were early generation isotransplants of a spontaneous C3H/Sed mouse fibrosarcoma, FSa-II. Single-cell suspensions were transplanted into the foot, and irradiation was given when each tumor reached an average diameter of 7 mm. Following irradiation, the tumor growth time to reach 1000 mm3 was studied and the dose-response curve between the tumor growth time and radiation dose was fitted. Preadministration of glucose increased the size of the hypoxic and chronically hypoxic cell fractions without altering the slope of the dose-response curve where the chronically hypoxic cell fraction is determined as the fraction of cells which were not oxygenated under hyperbaric oxygen conditions. Hyperthermia given prior to irradiation enhanced the tumor response to irradiation, but simultaneously increased the size of the hypoxic and chronically hypoxic cell fractions. Similar results were observed following hyperthermia given after irradiation. When hyperthermia at 43.5 degrees C was given 24 h before irradiation, the size of the hypoxic cell fraction increased with increasing treatment time, while a substantial decrease in the chronically hypoxic cell fraction was observed. Administration of glucose 60 min before hyperthermia further increased the size of the hypoxic cell fraction. Possible mechanisms explaining why glucose administration increases the hypoxic cell fractions are discussed.

• Research Organization: Harvard Medical School, Boston
• OSTI ID: 5625919
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 111:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMALS
ANOXIA
CARBOHYDRATES
CELL DIVISION
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
EXPERIMENTAL NEOPLASMS
GLUCOSE
HEXOSES
HYPERGLYCEMIA
MAMMALS
MEDICINE
MICE
MONOSACCHARIDES
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
RADIATION DOSES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RESPONSE MODIFYING FACTORS
RODENTS
SACCHARIDES
SARCOMAS
THERAPY
VERTEBRATES