Response of an experimental mammary carcinoma to fractionated x-irradiation with misonidazole and microwave hyperthermia
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
X/Gf mice bearing the MT2 mammary adenocarcinoma were subjected to 4000 rad of x rays given either as a single dose, or five daily fractions of 800 rad. Additional experimental groups were treated with either short term localized microwave hyperthermia (LMH), or the hypoxic cell radiosensitizer misonidazole (MISO), or both hyperthermia plus MISO with x rays. The combined use of MISO plus 42.5/sup 0/C with x rays was superior to the other treatment regimens as assessed by tumor regrowth delay and mean survival time. However, for the five fraction schedule, the addition of MISO plus hyperthermia was not as effective as observed for the single dose treatment. This may be attributed to reoxygenation of the hypoxic tumor cells between treatment fractions. MISO retention in tumor tissue under ambient and hyperthermic conditions was studied. The application of heat locally to the tumors caused a significant increase in MISO tumor concentration. However, after four x ray fractions the influence on MISO concentration by hyperthermia in the tumors could not be demonstrated.
- Research Organization:
- New York Univ., NY
- OSTI ID:
- 6354360
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:8; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effect of hyperthermia and misonidazole on the radiosensitivity of a transplant murine tumor: influence of factors modifying the fraction of hypoxic cells
Multiple daily fractionation (MDF) radiotherapy in association with hyperthermia and/or misonidazole: experimental and clincial results. [4. 5 MeV photons]
Misonidazole combined with hyperfractionation in the management of malignant glioma
Journal Article
·
Sun Aug 01 00:00:00 EDT 1982
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6514534
Multiple daily fractionation (MDF) radiotherapy in association with hyperthermia and/or misonidazole: experimental and clincial results. [4. 5 MeV photons]
Conference
·
Sun Jun 01 00:00:00 EDT 1980
· Cancer; (United States)
·
OSTI ID:5246755
Misonidazole combined with hyperfractionation in the management of malignant glioma
Journal Article
·
Sat Sep 01 00:00:00 EDT 1984
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6166568
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
560205 -- Thermal Effects-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY TEMPERATURE
CARCINOMAS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
FRACTIONATED IRRADIATION
GLANDS
GROWTH
HETEROCYCLIC COMPOUNDS
HYPERTHERMIA
IMIDAZOLES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MAMMARY GLANDS
MICE
MICROWAVE RADIATION
MISONIDAZOLE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RETENTION
RODENTS
VERTEBRATES
X RADIATION
560205 -- Thermal Effects-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY TEMPERATURE
CARCINOMAS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
FRACTIONATED IRRADIATION
GLANDS
GROWTH
HETEROCYCLIC COMPOUNDS
HYPERTHERMIA
IMIDAZOLES
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MAMMARY GLANDS
MICE
MICROWAVE RADIATION
MISONIDAZOLE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RETENTION
RODENTS
VERTEBRATES
X RADIATION