Multiple daily fractionation (MDF) radiotherapy in association with hyperthermia and/or misonidazole: experimental and clincial results. [4. 5 MeV photons]

Conference · Sun Jun 01 04:00:00 EDT 1980 · Cancer; (United States)

OSTI ID:5246755

Arcangeli, G ^[1]; Barocas, A; Mauro, F; Nervi, C; Spano, M; Tabocchini, A

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1. Instituto Medico Scientifico, Rome, Italy

Several modalities involving a Multiple Daily Fractionation (MDF) course in combination with hyperthermia and/or the hypoxic sensitizer misonidazole were tested on a mouse tumor system and then applied, with the proper sequencing, to a group of patients with multiple neck node metastases from H and N cancers. Different lesions of the same patients underwent different modalities. The clinical results indicate the effectiveness, in respect to a historical series of patients treated with conventional fractionation, of either MDF alone, or MDF + hyperthermia, or MDF + misonidazole, or MDF + hyperthermia + misonidazole. The latter modality appears to be possibly the most effective at inducing a complete local tumor response lasting longer in time. The pharmacology of misonidazole was monitored in the patients to avoid undesired excessive drug plasma level. No neurological symptoms were observed. Oropharyngeal mucositis was observed only in patients treated with misonidazole and radiation through two cross-firing portals. The problem of selecting individual patients for a particular modality is discussed.

• OSTI ID: 5246755
• Conference Information: Journal Name: Cancer; (United States) Journal Volume: 45:11
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
BODY TEMPERATURE
DIGESTIVE SYSTEM
DISEASES
DRUGS
EARLY RADIATION EFFECTS
ELEMENTARY PARTICLES
ENERGY RANGE
FRACTIONATED IRRADIATION
HYPERTHERMIA
INFLAMMATION
IRRADIATION
LOCAL IRRADIATION
MASSLESS PARTICLES
MEDICINE
METASTASES
MEV RANGE
MEV RANGE 01-10
MUCOUS MEMBRANES
NECK
NUCLEAR MEDICINE
ORAL CAVITY
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PHARYNX
PHOTONS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
SIDE EFFECTS
THERAPY