Inhibition of gastric secretion in guinea pig by relatively low dose ionizing radiation
Journal Article
·
· Proc. Soc. Exp. Biol. Med.; (United States)
We evaluated the effect of a single dose of ionizing radiation on gastric secretion in awake guinea pigs equipped with a permanent gastric cannula. Changes in gastric secretion were measured using a dye dilution technique. Infusion of histamine increased acid and fluid output and there was a positive correlation (r = 0.93) between the two. Total body irradiation with 400 cGy, like cimetidine, suppressed acid and fluid secretion under basal conditions and during histamine stimulation by 50-90%. Recovery from the radiation damage was only partial after one week. Irradiation inhibited the rise in gastric juice volume during histamine stimulation and also reduced the normal gain in body weight of the guinea pig. These results demonstrate that ionizing radiations have an immediate and long lasting effects on the gastric mucosal function of the guinea pig.
- Research Organization:
- Uniformed Services Univ. of the Health Sciences, Bethesda, MD (USA)
- OSTI ID:
- 6514349
- Journal Information:
- Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 189:2; ISSN PSEBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BODY FLUIDS
CELL CONSTITUENTS
CELL MEMBRANES
DIGESTIVE SYSTEM
EXTERNAL IRRADIATION
GASTRIC ACID
GASTROINTESTINAL TRACT
GUINEA PIGS
HETEROCYCLIC COMPOUNDS
HISTAMINE
IMIDAZOLES
INHIBITION
IONIZING RADIATIONS
IRRADIATION
LOW DOSE IRRADIATION
MAMMALS
MATERIALS
MEMBRANES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROSTAGLANDINS
RADIATION EFFECTS
RADIATIONS
RODENTS
SECRETION
VERTEBRATES
WHOLE-BODY IRRADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BODY FLUIDS
CELL CONSTITUENTS
CELL MEMBRANES
DIGESTIVE SYSTEM
EXTERNAL IRRADIATION
GASTRIC ACID
GASTROINTESTINAL TRACT
GUINEA PIGS
HETEROCYCLIC COMPOUNDS
HISTAMINE
IMIDAZOLES
INHIBITION
IONIZING RADIATIONS
IRRADIATION
LOW DOSE IRRADIATION
MAMMALS
MATERIALS
MEMBRANES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROSTAGLANDINS
RADIATION EFFECTS
RADIATIONS
RODENTS
SECRETION
VERTEBRATES
WHOLE-BODY IRRADIATION