Azide mutagenicity in mammalian cell culture

Technical Report · Sat Jan 01 00:00:00 EST 1977

OSTI ID:6508710

Jones, J A; Starkey, J; Kleinhofs, A

Sodium azide, a common laboratory and industrial chemical which has previously been shown to be mutagenic in bacteria and in barley, was demonstrated to be also highly mutagenic for the Chinese hamster cell lines V79 and V7979 and a rat liver cell line Lew A/sub 1/. It induced mutants at the gene loci governing 8-azaguanine and ouabain resistance at a frequency comparable with that following ethylmethane sulfonate treatment. This frequency was markedly enhanced in the moderately DNA repair deficient Chinese hamster subline V7979.

• Research Organization: Washington State Univ., Pullman (USA)
• DOE Contract Number: EY-76-C-06-2221-002
• OSTI ID: 6508710
• Report Number(s): RLO-2221/T2-36
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
GENE MUTATIONS
AZIDES
MUTAGEN SCREENING
MUTAGENESIS
BIOLOGICAL REPAIR
CELL CULTURES
COMPARATIVE EVALUATIONS
DNA
EMS
EXPERIMENTAL DATA
ISOLATED VALUES
MUTATION FREQUENCY
SODIUM COMPOUNDS
ALKALI METAL COMPOUNDS
BIOLOGICAL RECOVERY
DATA
DATA FORMS
ESTERS
INFORMATION
MUTAGENS
MUTATIONS
NITROGEN COMPOUNDS
NUCLEIC ACIDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RECOVERY
REPAIR
SCREENING
SULFONIC ACID ESTERS
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)
550300 - Cytology
550400 - Genetics