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U.S. Department of Energy
Office of Scientific and Technical Information

Azide mutagenicity in mammalian cell culture

Technical Report ·
OSTI ID:6508710
Sodium azide, a common laboratory and industrial chemical which has previously been shown to be mutagenic in bacteria and in barley, was demonstrated to be also highly mutagenic for the Chinese hamster cell lines V79 and V7979 and a rat liver cell line Lew A/sub 1/. It induced mutants at the gene loci governing 8-azaguanine and ouabain resistance at a frequency comparable with that following ethylmethane sulfonate treatment. This frequency was markedly enhanced in the moderately DNA repair deficient Chinese hamster subline V7979.
Research Organization:
Washington State Univ., Pullman (USA)
OSTI ID:
6508710
Report Number(s):
RLO-2221/T2-36
Country of Publication:
United States
Language:
English