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Effects of 12-O-tetradecanoylphorbol-13-acetate and mezerein on epidermal ornithine decarboxylase activity, isoproterenol-stimulated levels of cyclic adenosine 3':5'-monophosphate, and induction of mouse skin tumors in vivo

Journal Article · · Cancer Res.; (United States)
OSTI ID:6503455
 [1]; ; ; ; ;
  1. Univ. of Wisconsin, Madison
+ Show Author Affiliations

The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the antileukemic agent mezerein are diterpene esters of plant origin with certain structural similarities. Both compounds, when applied topically to mouse skin, were equipotent on a molar basis in inducing hyperplasia, inflammation, and ornithine decarboxylase activity, as well as in reducing cyclic adenosine 3':5-monophosphate accumulation in response to ..beta..-adrenergic stimulation. In contrast, mezerein was much less effective as a tumor promoter; the phorbol ester at 8.5 nmol/application yielded 78-fold more tumors than did 8.5 nmol mezerein per application to similarly initiated SENCAR mice. The superiority of the phorbol ester was nearly as great in CD-1 mice. These results suggest that although the induction of hyperplasia and ornithine decarboxylase activity may be necessary components of the carcinogenic process, they are not sufficient; 12-O-tetradecanoylphorbol-13-acetate must accomplish an essential event not accomplished by mezerein.

DOE Contract Number:
W-7405-ENG-26
OSTI ID:
6503455
Journal Information:
Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 39; ISSN CNREA
Country of Publication:
United States
Language:
English

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Related Subjects

550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANGULAR MOMENTUM
ANIMALS
CARBON-CARBON LYASES
CARBOXY-LYASES
CARBOXYLIC ACIDS
CARCINOGENESIS
CARCINOGENS
CATALYSIS
CELL PROLIFERATION
COMPARATIVE EVALUATIONS
DECARBOXYLASES
DISEASES
ENZYMES
ESTERS
IN VIVO
INFLAMMATION
LYASES
MAMMALS
METABOLISM
MICE
NEOPLASMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORNITHINE
PARTICLE PROPERTIES
PATHOGENESIS
PATHOLOGICAL CHANGES
PHORBOL ESTERS
RODENTS
SPIN
SYMPTOMS
TERPENES
TOXICITY
VERTEBRATES