Radiosensitization by diamide at low radiation doses
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:6500370
In vitro studies in this laboratory indicated that at low radiation doses (0-3 Gy), sensitization by misonidazole diminishes. The authors low dose assay uses a partially automated microscopic analysis procedure which scores both surviving and killed cells. If enough cells are scored, this assay provides much better accuracy at low doses than the conventional assay. Recently, they applied their low dose assay to a study of sensitization by diamide. At high doses (D = 6.5 to 10 Gy, S = 0.1 to 0.01) an enhancement ratio (ER) of 2.6 for hypoxic cells and 1.1 for aerobic cells was obtained. At low doses, 0-2.5 Gy, diamide still sensitized hypoxic cells well; the ER at 1 Gy (S = 0.8) was 2.0. The fact that diamide shows good sensitization at low doses with this assay adds to the credibility of the assay and reduces the likelihood that these observations with misonidazole are an artifact of this system.
- Research Organization:
- British Columbia Cancer Research Centre, Vancouver
- OSTI ID:
- 6500370
- Report Number(s):
- CONF-8311204-
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 10:8
- Country of Publication:
- United States
- Language:
- English
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Increased radiosensitivity of aerobic mammalian cells following pre-incubation with misonidazole in hypoxia
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Conference
·
Wed Aug 01 00:00:00 EDT 1984
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:6408234
Irradiation of mammalian cells in the presence of diamide and low concentrations of oxygen at conventional and at ultrahigh dose rates
Journal Article
·
Mon Feb 28 23:00:00 EST 1983
· Radiat. Res.; (United States)
·
OSTI ID:5682852
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Journal Article
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Wed Oct 31 23:00:00 EST 1984
· Radiat. Res.; (United States)
·
OSTI ID:5931844
Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMAL CELLS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
CHO CELLS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
LOW DOSE IRRADIATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
SURVIVAL CURVES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMAL CELLS
ANOXIA
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
CHO CELLS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
IRRADIATION
LOW DOSE IRRADIATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
SURVIVAL CURVES
X RADIATION