Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Effect of misonidazole as a hypoxic radiosensitizer at low dose

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576355· OSTI ID:5931844
; ;
Using an automated low dose survival assay, the radiosensitizing effectiveness of misonidazole at low radiation dose (0-6 Gy) was measured in cultured mammallian cells. Also measured was its effectiveness at high doses of radiation (0-35 Gy) using the conventional survival assay. In both cases, several concentrations of the drug from 0 to 5 mM were used. The data at low doses were analyzed by a two-parameter mathematical equation with linear and quadratic dose terms which proved to be a good fit to the experimental data at all misonidazole concentrations. The enhancement ratio (ER) of misonidazole is shown to be decreased at lower doses. The clinical implications of this result are discussed.
Research Organization:
British Columbia Research Centre, Vancouver
OSTI ID:
5931844
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 100:2; ISSN RAREA
Country of Publication:
United States
Language:
English

Similar Records

Radiosensitization by diamide at low radiation doses
Conference · Wed Aug 01 00:00:00 EDT 1984 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:6500370
Interaction of misonidazole and oxygen in the radiosensitization of mammalian cells
Journal Article · Thu May 01 00:00:00 EDT 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States) · OSTI ID:6839327
Low concentrations of nitroimidazoles: Effective radiosensitizers at low doses
Journal Article · Sat Apr 30 00:00:00 EDT 1994 · International Journal of Radiation Oncology, Biology and Physics; (United States) · OSTI ID:6901191

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANOXIA
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL KILLING
CHO CELLS
DATA
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
INFORMATION
IONIZING RADIATIONS
IRRADIATION
LOW DOSE IRRADIATION
MATHEMATICAL MODELS
MISONIDAZOLE
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
SURVIVAL CURVES
X RADIATION