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Increased radiosensitivity of aerobic mammalian cells following pre-incubation with misonidazole in hypoxia

Conference · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:6408234
The effect of pre-incubation of CHO cells with misonidazole in hypoxia on the aerobic radiosensitivity of these same cells was observed and analyzed according to the concepts of independent and additive interaction. It was found that the sensitivity of cells irradiated in air, in the presence or absence of misonidazole, increased when the cells had been pre-incubated with misonidazole in hypoxia at 37/sup 0/C. This increase in aerobic radiosensitivity was evident as a loss of the shoulder of the survival curve, and the data were consistent with an additive, rather than an independent interaction mechanism. These data are consistent with the previous work with hypoxic cells, and support the hypothesis that a toxic metabolite of the sensitizer is produced during hypoxic incubation, whose effect is manifested as an additional increment of cell killing equivalent to an additional dose of radiation.
Research Organization:
Massachusetts General Hospital, Boston
OSTI ID:
6408234
Report Number(s):
CONF-8311204-
Conference Information:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 10:8
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANOXIA
ANTINEOPLASTIC DRUGS
AZOLES
CELL KILLING
CHO CELLS
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
MISONIDAZOLE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
SURVIVAL CURVES
X RADIATION