Breaks induced in the deoxyribonucleic acid of aerosolized Escherichia coli by ozonized cyclohexene

Journal Article · Sat Dec 31 23:00:00 EST 1977 · Appl. Environ. Microbiol.; (United States)

OSTI ID:6499963

De Mik, G; De Groot, I

The inactivation of aerosolized Escherichia coli by ozone, cyclohexene, and ozonized cyclohexene was studied. The parameters for damage were loss of reproduction and introduction of breaks in the deoxyribonucleic acid (DNA). Aerosolization of E. coli in clean air at 80% relative humidity or in air containing either ozone or cyclohexene hardly affected survival; however, some breaks per DNA molecule were induced, as shown by sucrose gradient sedimentation of the DNA. Aerosolization of E. coli in air containing ozonized cyclohexene at 80% relative humidity decreased the survival by a factor of 10/sup 3/ or more after 1 h of exposure and induced many breaks in the DNA.

• Research Organization: Medical Biological Lab., TNO, Rijswijk, Netherlands
• OSTI ID: 6499963
• Journal Information: Appl. Environ. Microbiol.; (United States), Journal Name: Appl. Environ. Microbiol.; (United States) Vol. 35:1; ISSN AEMID
• Country of Publication: United States
• Language: English

Related Subjects

560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKANES
BACTERIA
BIOLOGICAL EFFECTS
CYCLOALKANES
CYCLOHEXANE
DNA
ESCHERICHIA COLI
HYDROCARBONS
INJURIES
MICROORGANISMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
OZONE