Enhancement of hepatic detoxification enzyme activity by dietary mercuric acetate

Journal Article · Mon Jan 01 04:00:00 EST 1973 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01856764· OSTI ID:6498386

Wagstaff, D J

This report deals with stimulation of liver microsomal enzymes by dietary mercuric acetate (HgAc) and interactions of HgAc with phenobarbital sodium (PB). There is a diphasic response of microsomal enzymes in rats exposed to mercurials. Detoxication activity increased as the dietary dose of HgAc was increased. Liver weight was unaffected by ingestion of HgAc . Toxicity of HgAc increased with dosage. There were no deaths among animals fed diets of 2000 ppM HgAc or less but all five animals fed the diet of 5000 ppM died after five but before ten days on the experiment. The mercury-phenobarbital interactions support speculation that mercury in combination with other chemicals in the environment may have enzyme stimulatory capacity at low exposure levels. 25 references, 1 figure, 1 table.

• Research Organization: Univ. of Missouri, Columbia
• OSTI ID: 6498386
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 9:1; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETATES
ANESTHETICS
ANIMALS
ANTICONVULSANTS
AZINES
BARBITURATES
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACID SALTS
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DETOXIFICATION
DIET
DIGESTIVE SYSTEM
DRUGS
ENZYME REACTIVATION
GLANDS
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
LIVER
MAMMALS
MERCURY COMPOUNDS
MICROSOMES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
PHENOBARBITAL
PYRIMIDINES
RATS
RODENTS
TOXICITY
VERTEBRATES