Effects of dietary lead acetate on hepatic detoxication enzyme activity

Journal Article · Sat Dec 01 04:00:00 EST 1979 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01770037· OSTI ID:5209823

Wagstaff, D J

Lead-containing compounds usually inhibit enzymic and metabolic processes. This inhibition is presumed to be the mechanism of intoxication by these compounds. Inhibition of detoxication activities of liver microsomal enzymes could be particularly detrimental because the toxicity of many different substances would be increased. Exposure of experimental animals to lead compounds in several studies has been associated with depressed activity of hepatic microsomal enzymes, reduced levels of hepatic cytochrome P-450, reduced levels of hepatic microsomal protein, and prolonged hexobarbital sleep times. The present report contains observations that under certain experimental conditions there is stimulated hepatic meicrosomal enzyme activity in rats fed lead acetate.

• Research Organization: Food and Drug Administration, Washington, DC
• OSTI ID: 5209823
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Journal Name: Bull. Environ. Contam. Toxicol.; (United States) Vol. 23:6; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
ELEMENTS
ENZYME INHIBITORS
ENZYMES
GLANDS
LEAD
LEAD COMPOUNDS
LIVER
MAMMALS
METALS
ORGANIC COMPOUNDS
ORGANS
PHYSIOLOGY
PROTEINS
RATS
RODENTS
SLEEP
TOXICITY
VERTEBRATES