Cadmium effect on microsomal drug-metabolizing enzyme activity in rat livers with respect to differences in age and sex

Journal Article · Thu Apr 01 04:00:00 EST 1982 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(82)90099-8· OSTI ID:5428848

Ando, M

The effect of cadmium on the hepatic microsomal drug-metabolizing enzyme system was investigated. Cadmium chloride caused the conversion of cytochrome P-450 to P-420 in rat liver microsomes. The destruction of cytochrome P-450 by cadmium caused the reduction of microsomal drug-metabolizing enzyme activity and prolonged the pentobarbital sleeping time. There is a sex-related difference in the ability of cadmium to inhibit the hepatic drug metabolism in rats: male rats are more sensitive to cadmium than females. The effective period when cadmium prolonged their sleep depended upon the age of rats; older rats were more sensitive to cadmium than younger ones. The maximum increase of sleeping time depended upon the dose level of cadium, and the rate constant of the equations seems to depend upon the age of the animals.

• Research Organization: National Inst. for Environmental Studies, Yatabe, Japan
• OSTI ID: 5428848
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 27:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANESTHETICS
ANIMALS
AZINES
BARBITURATES
BIOLOGICAL EFFECTS
BODY
CADMIUM
CELL CONSTITUENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CYTOCHROMES
DIGESTIVE SYSTEM
DRUGS
ELEMENTS
ENZYME ACTIVITY
ENZYME INHIBITORS
GLANDS
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
LIVER
MAMMALS
METALS
MICROSOMES
NEMBUTAL
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
ORGANS
PIGMENTS
PYRIMIDINES
RATS
RODENTS
SEX DEPENDENCE
VERTEBRATES