Mercuric chloride effects on the activities of some hepatic enzymes in chicks
Three groups of 6 male chicks each were fed a commercial diet and were given drinking water which contained either 0, 150 or 300 ..mu..g of mercury/ml. as mercuric chloride from hatching to 3 weeks of age. The chicks were killed, the livers were removed and weighed, and the activities of selected enzymes were measured in the 800 x g/sub av/ supernatant fractions of the liver homogenates. Liver weights were depressed from control values in chicks receiving 300 p.p.m. mercury but not in chicks receiving 150 p.p.m. Fatty acid synthetase specific activity was depressed by both levels of added mercury, but microsomal fatty acid elongation was depressed only by 300 p.p.m. of mercury. Both levels of added mercury stimulated acid phosphatase specific activity. The specific activities of cytochrome c oxidase, glucose-6-phosphatase and 6-phosphogluconate dehydrogenase were unaffected by added mercury. The data support the hypothesis that mercury administration does not result in generalized hepatotoxicity. 22 references, 1 table.
- Research Organization:
- North Carolina State Univ., Raleigh
- OSTI ID:
- 5093236
- Journal Information:
- Poult. Sci.; (United States), Journal Name: Poult. Sci.; (United States) Vol. 54:5; ISSN POSCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID PHOSPHATASE
ANIMALS
BIOLOGICAL EFFECTS
BIRDS
BODY
CHICKENS
CHLORIDES
CHLORINE COMPOUNDS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ENZYME ACTIVITY
ENZYMES
ESTERASES
FOWL
GLANDS
HALIDES
HALOGEN COMPOUNDS
HYDROLASES
INHIBITION
LIVER
MERCURY CHLORIDES
MERCURY COMPOUNDS
MERCURY HALIDES
ORGANS
OXIDOREDUCTASES
PHOSPHATASES
VERTEBRATES