X-radiation-induced differentiation of xenotransplanted human undifferentiated rhabdomyosarcoma
Journal Article
·
· Lab. Invest.; (United States)
OSTI ID:6496797
A serially xenotransplantable strain of undifferentiated embryonal rhabdomyosarcoma originating from the nasal cavity of a 42-year-old woman has been established in our laboratory. After radiotherapy for the tumor donor, distinct rhabdomyoblastic differentiation of the undifferentiated sarcoma cells appeared in the primary lesion, and it is a reasonable assumption that X-irradiation has a certain potentiality to induce morphologic differentiation of tumor cells. To study this possibility, tissue fragments of undifferentiated embryonal rhabdomyosarcoma that had grown to more than 10 mm after being transplanted to nude mice were selectively irradiated in situ. The degree of rhabdomyoblastic differentiation according to radiation dose was evaluated by light and electron microscopy and by immunostainability for myoglobin, creatine phosphokinase-MM, and desmin. Distinct morphologic differentiation of undifferentiated sarcoma cells could be induced by repeated X-irradiations at several-week intervals.
- Research Organization:
- Tokyo Metropolitan Komagome Hospital (Japan)
- OSTI ID:
- 6496797
- Journal Information:
- Lab. Invest.; (United States), Journal Name: Lab. Invest.; (United States) Vol. 60:1; ISSN LAINA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BODY
BODY AREAS
CARBOXYLIC ACIDS
CELL DIFFERENTIATION
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRON MICROSCOPY
EXPERIMENTAL NEOPLASMS
FACE
FRACTIONATED IRRADIATION
GLOBIN
HEAD
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
MICROSCOPY
MYOGLOBIN
NEOPLASMS
NOSE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
RADIATIONS
RADIOINDUCTION
RESPIRATORY SYSTEM
RODENTS
SARCOMAS
TRANSPLANTS
TUMOR CELLS
VERTEBRATES
X RADIATION
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BODY
BODY AREAS
CARBOXYLIC ACIDS
CELL DIFFERENTIATION
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRON MICROSCOPY
EXPERIMENTAL NEOPLASMS
FACE
FRACTIONATED IRRADIATION
GLOBIN
HEAD
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
MICROSCOPY
MYOGLOBIN
NEOPLASMS
NOSE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PORPHYRINS
PROTEINS
RADIATIONS
RADIOINDUCTION
RESPIRATORY SYSTEM
RODENTS
SARCOMAS
TRANSPLANTS
TUMOR CELLS
VERTEBRATES
X RADIATION