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Human exposure to ferric sulfate aerosol: effects on pulmonary function and respiratory symptoms

Journal Article · · Am. Ind. Hyg. Assoc. J.; (United States)
; ; ; ; ; ;

Twenty normal and 18 asthmatic human volunteers were exposed to ferric sulfate aerosol at a nominal concentration of 75 ..mu..g/m/sup 3/ (equivalent to 20 ..mu..g iron/m/sup 3/). The concentration and particle size distribution were selected to simulate worst case ambient conditions. A double-blind protocol was followed in which each subject was exposed on two days, separated by about a three week period. The subjects were exposed to clean air (sham) on one day and to ferric sulfate aerosol on the other (exposure); the order of exposure was selected randomly. Pulmonary function tests were performed immediately before (pre) and after (post) each 2 h sham or exposure period; this protocol included intermittent excercise. On the average, the two groups of subjects did not exhibit significant pre- to post-changes in total respiratory system resistance, forced expiratory flow/volume performance, and single breath nitrogen washout parameters. None of the subjects reported more than slight changes in symptoms during exposure.

Research Organization:
Univ. of Southern California, Downey
OSTI ID:
6495573
Journal Information:
Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 42:4; ISSN AIHAA
Country of Publication:
United States
Language:
English

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Related Subjects

500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
ASTHMA
BIOLOGICAL EFFECTS
COLLOIDS
DISEASES
DISPERSIONS
INHALATION
INTAKE
IRON COMPOUNDS
IRON SULFATES
MAMMALS
MAN
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PRIMATES
RESPIRATION
RESPIRATORY SYSTEM DISEASES
SOLS
SULFATES
SULFUR COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES