Respiratory responses of exercising asthmatic volunteers exposed to sulfuric acid aerosol

Journal Article · Mon Dec 01 04:00:00 EST 1986 · J. Air Pollut. Control Assoc.; (United States)

DOI:https://doi.org/10.1080/00022470.1986.10466181· OSTI ID:6840351

Linn, W S; Avol, E L; Shamoo, D A; Whynot, J D; Anderson, K R; Hackney, J D

Young asthmatic adult volunteers (N = 27) were exposed in an environmental chamber to sulfuric acid aerosol at concentrations near 0, 122, 242, and 410 ..mu..g/m/sup 3/, in purified background air at 22/sup 0/C and 50 percent relative humidity. The polydisperse aerosol had a mass median aerodynamic diameter near 0.6 ..mu..m. Exposures occurred in random order at one-week intervals. Each lasted 1 h, during which subjects exercised (mean ventilation 42 L/min) and rested during alternate 10-min periods. Specific airway resistance and forced expiratory function were measured pre-exposure, after the initial exercise, and at end-exposure. Bronchial reactivity was determined by challenge with cold air immediately post-exposure. Symptoms were monitored during exposure for one week afterward. Exercise-induced bronchospasm was observed under all conditions. Physiologic and symptom changes possibly attributable to sulfuric acid exposure were small and not statistically significant. Our largely negative results contrast with positive findings elsewhere at lower acid doses. Possible explanations include different clinical characteristics of subjects and different routes of breathing.

• Research Organization: Univ. of Southern California School of Medicine, Downey
• OSTI ID: 6840351
• Journal Information: J. Air Pollut. Control Assoc.; (United States), Journal Name: J. Air Pollut. Control Assoc.; (United States) Vol. 36:12; ISSN JPCAA
• Country of Publication: United States
• Language: English

Related Subjects

500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
ASTHMA
DISEASES
ECOLOGICAL CONCENTRATION
EXERCISE
EXPOSURE CHAMBERS
HAZARDS
HEALTH HAZARDS
HYDROGEN COMPOUNDS
INORGANIC ACIDS
MAMMALS
MAN
PARTICLE SIZE
PATHOGENESIS
POLLUTION
PRIMATES
RESPIRATORY SYSTEM DISEASES
SIZE
SULFURIC ACID
SYMPTOMS
VERTEBRATES