New germanium-68/gallium-68 generator
A germanium--gallium generator producing EDTA-free /sup 68/Ga would permit the synthesis of a broad range of /sup 68/Ga radiopharmaceuticals and thus facilitate the widespread application of positron tomography. We have investigated a solvent-extraction generator system producing the weak complex of /sup 68/Ga with 8-hydroxyquinoline (/sup 68/Ga oxin), free of EDTA. The conditions for optimum /sup 68/Ga yield and minimum /sup 68/Ge breakthrough involve extraction with chloroform from pH 5 buffer containing Ge/sup 4 +/ carrier, followed by evaporation to dryness. This produces /sup 68/Ga yields of 70 to 80%, with /sup 68/Ge breakthrough of <0.003%. The /sup 68/Ga oxine is readily converted to other radiopharmaceuticals such as /sup 68/Ga EDTA, /sup 68/Ga EDTMP, or /sup 68/Ga colloid, and is conveniently delivered dry. The extraction system is simple and amenable to automation, and the low loss rate and 280-day half-life of /sup 68/Ge provide a generator with a long useful lifetime.
- Research Organization:
- Washington Univ., St. Louis, MO
- OSTI ID:
- 6485029
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 19:8
- Country of Publication:
- United States
- Language:
- English
Similar Records
Preparation of gallium-68 radiopharmaceuticals for positron tomography. Progress report, November 1, 1977-October 31, 1980
Preparation of gallium-68 radiopharmaceuticals for positron tomography. Progress report, November 1, 1978-October 31, 1979
Related Subjects
GALLIUM 68
ISOTOPE PRODUCTION
GERMANIUM 68
OXINE
RADIOISOTOPE GENERATORS
RADIOPHARMACEUTICALS
SOLVENT EXTRACTION
AZINES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
EXTRACTION
GALLIUM ISOTOPES
GERMANIUM ISOTOPES
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
QUINOLINES
RADIOACTIVE MATERIALS
RADIOISOTOPES
SEPARATION PROCESSES
400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production