Preparation of gallium-68 radiopharmaceuticals for positron tomography. Progress report, November 1, 1980-December 31, 1981

Technical Report · Mon Jun 01 04:00:00 EDT 1981

OSTI ID:6299356

Welch, M J

Although the germanium-68 ..-->.. gallium-68 generator is probably the only source of positron-emitting radionuclides that could enable the widespread application of positron tomography, the commercially available /sup 68/Ga//sup 68/Ge generator system suffers from several major disadvantages. The most important of these is that the generator is eluted with EDTA, which forms a very strong chelate with gallium. In order to produce radiopharmaceuticals other than /sup 68/Ga-EDTA, it is first necessary to break the stable EDTA complex and remove all traces of EDTA. This procedure adds several steps and a significant amount of time to procedures for preparing /sup 68/Ga-radiopharmaceuticals. Several years ago, we developed a new generator using a solvent extraction system which produces /sup 68/Ga-oxine (8-hydroxyquinoline), a weak chelate. We have also carried out studies to compare generator systems which produce /sup 68/Ga in an ionic form. Using the gallium-68 eluted from these various generator systems, several /sup 68/Ga-labeled radiopharmaceuticals have been synthesized and tested in vitro and in vivo. In addition, attempts have been made to design and synthesize a lipophilic ligand for gallium-68. The stability of radiogallium complexed with a series of potentially lipophilic complexing agents has been studied using chromatographic techniques and in vivo distribution data. The potential of these complexing agents for altering the biodistribution of gallium radiopharmaceuticals has also been investigated.

• Research Organization: Washington Univ., St. Louis, MO (USA). Edward Mallinckrodt Inst. of Radiology
• DOE Contract Number: AS02-77EV04318
• OSTI ID: 6299356
• Report Number(s): DOE/EV/04318-4; ON: DE81029092
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AZINES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CHELATES
CHEMICAL PREPARATION
COMPLEXES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EXTRACTION
GALLIUM 68
GALLIUM ISOTOPES
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPE PRODUCTION
ISOTOPES
LABELLED COMPOUNDS
LIGANDS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXINE
POSITRON COMPUTED TOMOGRAPHY
PYRIDINES
QUINOLINES
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SEPARATION PROCESSES
SOLVENT EXTRACTION
SYNTHESIS
TOMOGRAPHY