Preparation of gallium-68 radiopharmaceuticals for positron tomography. Progress report, November 1, 1978-October 31, 1979

Technical Report · Thu Jun 01 04:00:00 EDT 1978

DOI:https://doi.org/10.2172/5772226· OSTI ID:5772226

Welch, M J

Although the germanium-gallium generator is probably the only source of positron-emitting radionuclides that would enable the wide application of positron tomography, the generator system in use suffers from several major disadvantages. The most important of these is that the generator is eluted with EDTA, and EDTA forms a very strong chelate with gallium. In order to produce radiopharmaceuticals other than gallium-68 EDTA it is necessary to break the stable EDTA complex and remove all the EDTA. A new generator system using a solvent extraction system which will produce gallium-68 8-hydroxyquinoline, a weak chelate has been developed. Using this agent, several gallium-68 radiopharmaceuticals have been synthesized and tested in vitro and in vivo. Attempts have been made using polarographic and chromatographic techniques to investigate the stability of gallium-68 complexes with a series of cryptates.

• Research Organization: Washington Univ., St. Louis, MO (USA). Edward Mallinckrodt Inst. of Radiology
• DOE Contract Number: EE-77-S-02-4318
• OSTI ID: 5772226
• Report Number(s): COO-4318-2
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703* -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
AMINO ACIDS
AZINES
BEAMS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHELATING AGENTS
CHROMATOGRAPHY
COMPLEXES
DRUGS
EDTA
ELEMENTS
GALLIUM 68
GALLIUM COMPLEXES
GALLIUM ISOTOPES
GERMANIUM
HETEROCYCLIC COMPOUNDS
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPE PRODUCTION
ISOTOPES
LABELLED COMPOUNDS
LEPTON BEAMS
METALS
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXINE
PARTICLE BEAMS
POLAROGRAPHY
POSITRON BEAMS
PYRIDINES
QUINOLINES
RADIOACTIVE MATERIALS
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SEPARATION PROCESSES
STABILITY
SYNTHESIS
TOMOGRAPHY