Preparation of gallium-68 radiopharmaceuticals for positron tomography. Progress report, November 1, 1980 - December 31, 1983

Technical Report · Mon Aug 01 04:00:00 EDT 1983

OSTI ID:5744932

Welch, M J

The germanium-68/gallium-68 generator system is an ideal generator system for carrying out studies using positron-emission tomography in institutions without an in-house cyclotron. We have compared two new generator systems with a commercially available system and conclude that the preferred system is a stannous oxide column from which the gallium-68 is eluted using hydrochloric acid. We have attempted to prepare a series of lipophilic gallium radiopharmaceuticals for use in the measurement of cerebral and myocardial blood flow. As part of this study, we have attempted to define the ranges of lipophilicility and molecular weight necessary for an agent to be a suitable flow tracer. Our data suggest that, although gallium radiopharmaceuticals based on the enterobactin structure are stable in vivo, their molecular weights are too high for use as flow tracers. A series of salicylimines recently developed appear to have potential for use as gallium-68 flow tracers.

• Research Organization: Washington Univ., St. Louis, MO (USA). Edward Mallinckrodt Inst. of Radiology
• DOE Contract Number: AC02-77EV04318
• OSTI ID: 5744932
• Report Number(s): DOE/EV/04318-5; ON: DE83017109
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703 -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
CHEMICAL PREPARATION
CHEMICAL PROPERTIES
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-EVEN NUCLEI
GALLIUM 68
GALLIUM ISOTOPES
GERMANIUM 68
GERMANIUM ISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-ODD NUCLEI
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SYNTHESIS
TOMOGRAPHY
TRACER TECHNIQUES