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Enhancement of adenoma formation in mouse lung by butylated hydroxytoluene

Journal Article · · Toxicol. Appl. Pharmacol.; (United States)
;

Male mice, 6 to 8 weeks old, were injected ip with a single dose of urethan, an agent known to produce lung adenomata within 14 to 24 weeks after administration. When urethan was followed by weekly ip administrations of butylated hydroxytoluene (BHT), the number of tumors per lung found 14 to 24 weeks after urethan was increased. Increased number of tumors per lung were also found when the interval between urethan injection and the first BHT treatment was extended up to 6 weeks. When the total number of BHT injections was reduced from 13 to 4, tumor development was still enhanced. Repeated treatment with BHT, followed by urethan, had no effect and concomitant administration of urethan and BHT reduced the number of tumors found. BHT did not produce more tumors per lung in mouse strains resistant to adenoma formation. It is concluded that, in mouse lung, BHT has several properties of a promoting agent for urethan-initiated adenoma formation.

Research Organization:
Univ. of Montreal, Canada
OSTI ID:
6482018
Journal Information:
Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 50; ISSN TXAPA
Country of Publication:
United States
Language:
English

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Related Subjects

551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOMAS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CARCINOGENESIS
DISEASES
HYDROXY COMPOUNDS
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
LUNGS
MAMMALS
MICE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PROMOTERS
RESPIRATORY SYSTEM
RODENTS
SENSITIVITY
SYNERGISM
TUMOR PROMOTERS
URETHANE
VERTEBRATES