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Butylated hydroxyanisole and lung tumor development in A/J mice

Journal Article · · Fundam. Appl. Toxicol.; (United States)
;

A diet containing 0.75% butylated hydroxyanisole (BHA) did not enhance the development of lung tumors in A/J mice if fed for 8 weeks after administration of urethane, benzo(a)pyrene (B(a)P), or dimethylnitrosamine (DMN). Prefeeding animals with BHA partially protected animals against the tumorigenic effect of urethane and B(a)P. Partial protection was also seen in animals given B(a)P and then exposed to BHA in the diet. The two isomers of BHA 3-tert.-butyl-4-hydroxyanisole and 2-tert.-butyl-4-hydroxyanisole) were synthesized and injected ip. They failed to enhance lung tumor development. It is concluded that BHA is not a promoting agent as is butylated hydroxytoluene (BHT) for lung tumors in mice. One possible explanation is that BHA in the diet does not produce the extensive cell proliferation seen in the lungs of mice fed BHT. 19 references, 5 tables.

Research Organization:
Oak Ridge National Lab., TN
DOE Contract Number:
W-7405-ENG-26
OSTI ID:
5193560
Journal Information:
Fundam. Appl. Toxicol.; (United States), Journal Name: Fundam. Appl. Toxicol.; (United States) Vol. 4; ISSN FAATD
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
ANTIOXIDANTS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BODY
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CARCINOGENESIS
CELL PROLIFERATION
CONDENSED AROMATICS
DATA
DIET
DISEASES
EXPERIMENTAL DATA
HYDROCARBONS
INFORMATION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
LUNGS
MAMMALS
MICE
NEOPLASMS
NITROSAMINES
NITROSO COMPOUNDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PROMOTERS
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
RODENTS
TUMOR PROMOTERS
URETHANE
VERTEBRATES